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Sumatriptan succinate is chemically designated as 3-[2-(dimethylamino)ethyl]­. Swallow your Imitrex as soon as you feel the first signs of migraine headache pain. Imitrex is a brand-name prescription medication. Before taking Imitrex, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Migraine headaches are believed to be stipulated by widening. The 5-mg and 20-mg doses are given as a single spray in 1 nostril Typically, your doctor will prescribe a low or moderate starting dose of Imitrex. Imitrex will only treat a headache. Sumatriptan is a drug that is used for treating migraine attacks with or without the presence of an aura, to relieve cluster headache attacks. DESCRIPTION IMITREX (sumatriptan succinate) Injection is a selective 5-hydroxytryptamine 1 receptor subtype agonist. The osmolality of both injections is 291 mOsmol. It’s FDA-approved to treat migraine with or without aura. 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